Cancer cachexia is a multifactorial, common but often underrecognized, debilitating clinical condition1-5, shown to adversely impact patients’ tolerance and response to anticancer therapy5-9, as well as the survival of patients with advanced tumors9-14. Across all tumor types, more than 50% of patients with cancer develop cachexia, with a prevalence of up to 80% in patients with advanced cancers1; the condition has particularly high prevalence among patients with gastrointestinal (GI) and non-small cell lung cancers2. Cancer cachexia is often underrecognized, inadequately managed, and considered inevitable for patients with cancer3,4.

Weight loss and anorexia are key clinical hallmarks of cancer cachexia17 correlated with shorter survival9-14; mortality among patients with cancer cachexia is estimated at 80%, with over 30% of deaths linked to cancer cachexia1. Weight and skeletal muscle mass loss are associated with metabolic dysfunction and cannot be fully reversed by conventional nutritional support16-17.

Weight loss during cancer treatment has been associated with an increase in therapy-related toxicities5-8, negatively interfering with completion of therapy cycles15 and impairing response to cancer treatment9.

Current treatment approaches for cancer cachexia have limited success18-21, with no available options to substantially improve LBM22 and potentially counteract the metabolic impairment associated with muscle depletion.


  1. von Haehling S, Anker SD. J Cachexia Sarcopenia Muscle 2010;1:1–5.
  2. Del Ferraro C, et al. J Hosp Palliat Nurs 2012;14.
  3. Benner A, et al. Support Care Cancer 2013;21(Suppl 1): abstract 0808.
  4. Muscaritoli M, et al. Ann Oncol 2016;27:2230–2236.
  5. Fukahori M, et al. Support Care Cancer 2021;29:341–348.
  6. da Rocha IMG, et al. J Cachexia Sarcopenia Muscle 2019;10:445–454.
  7. Mitsunaga S, et al. Support Care Cancer 2020;28:5271–5279.
  8. Molfino A, et al. Clin Nutr 2021;
  9. Roch B, et al. Lung Cancer 2020;143:19–26.
  10. Gallois C, et al. Clin Res Hepatol Gastroenterol 2021;45:101603.
  11. Guercio BJ, et al. JNCI Cancer Spectr 2020;4:pkaa024.
  12. Kim KW, et al. BMC Cancer 2021;21:157.