Helsinn

Swiss Site

	Helsinn Chemicals SA Switzerland	Helsinn Advanced Synthesis SA Switzerland
Employees	82	23

R&D Product Development	Yes	Yes

cGMP Scale-up Plant for API
Total capacity	450 liters
Reactors	1 x 100 L (GL), 1 x 100 L (SS)
	1 x 250 L (GL)
Temperature ranges	-15°C to 150°C
Pressure ranges	Up to 5 bars
Product isolation	Vertical Peeler Centrifuge

cGMP Production Plant
Total capacity	46'000 liters	24'000 liters
Reactor	1 x 1000 L (GL), 1 x 1000 L (HL)	5 x 4000 L (GL)
	1 x 2500 L (GL), 1 x 2500 L (SS)	1 x 4000 L (HL)
	4 x 4000 L (GL), 4 x 4000 L (SS)
	1 x 6300 L (GL), 1 X 6300 L (SS)
Temperature ranges	-15°C to 150°C	-15°C to 150°C
Pressure ranges	Up to 5 bars	Up to 5 bars
Product isolation	2 x Horizontal Peeler Centrifuges, 3 x Vertical Peeler Centrifuges, 1 x Pressure filter	2 x Horizontal Peeler Centrifuges 1 x 0.8m2 Hastelloy pressure-filter-dryer 1 x 2.5m2 Hastelloy pressure-filter-dryer

Drying and Finishing
Total capacity	12'000 L	4'000 L
Biconic dryer sizes	2 x 2'000 L, 2 x 4'000 L	1 x 4'000 L
Class 100'000 drying unit	Yes *	-
Micronization	Jetmill MS35 micronizer	-
* Meets class 100'000 requirements

Future expansion possibility in the actual plants
APIs and Advanced Intermediates	Max 24'000 L	Max 24'000 L
GL : Glass-lined
SS : Stainless steel
HL : Hastelloy

Irish Site

	Helsinn Chemicals Ireland Ltd. Ireland
Employees	37

R&D Product Development	Yes

cGMP Scale-up Plant
Total capacity	60 liters
Reactor sizes	2 x 30 L Glass reactors
Temperature ranges	-10°C to 150°C
Pressure ranges	Up to 1 bar
Product isolation	Filter, Rotary Dryer

cGMP Production Plant
Total capacity	43’000 liters
Reactor sizes	2 x 4000 L (GL), 3 x 6300 L (GL), 1 x 8000 L (GL), 1 x 8000 L (SS)
Temperature ranges	-10°C to 150°C
Pressure ranges	Up to 5 bars
Product isolation 2 x Vertical Peeler Centrifuges	1 x Horizontal Peeler Centrifuges

Drying and Finishing
Total capacity	11'500 L
Biconic dryer sizes	2 x 4000 L, 1 x 3500 L 1 x Hosakowa-micron 12S Finishing Mill
Class 100'000 drying unit	Yes *
Micronization	Jet-Mill MS35, semi automatic *
Milling
Blending	• 800 L double cone blender
* Meets class 100'000 requirements