Producing right now a total of 28 different compounds for the Pharmaceutical industry. Advanced Intermediates, Active Pharmaceutical Ingredients (API) and High Potency Active Ingredients (HPAI) in containment areas (class 3 according to SafeBridge).

Helsinn Chemicals SA and Helsinn Advanced Synthesis SA – Switzerland

Ideal for manufacturing of clinical batches and commercial routine production. Producing Advanced Intermediates, Active Pharmaceutical Ingredients and High Potency Active Ingredients in containment areas (class 3 according to SafeBridge)

Reactors	Total reaction volume of 70.1 m3
Pressures	up to 5 bars
Temperatures	-10°C up to 150°C
Isolation	Horizontal and vertical peeler centrifuges
	Hastelloy pressure-filter-dryers (0.8 and 2.5 m2 surface)
	2000 and 4000 liter Bicone dryers for intermediates
Finishing plant	2000 and 4000 liter Bicone dryers for API in contained area
	Could be classified class 100’000 or 10’000
	Jet-mill micronizer

Helsinn Chemicals Ireland Ltd

Ideal for the manufacturing of commercial routine production. The newly refurbished cGMP small scale manufacturing plant is also available for small (< 10 kg / batch) clinical batches. Producing Advanced Intermediates and Active Pharmaceutical Ingredients.

Reactors	Total reaction volume of 43 m3
	Reactors from 4000 up to 10’000 Liters (stainless steel and glass-lined)
Pressures	up to 5 bars
Temperatures	-10°C up to 150°C
Isolation	Horizontal peeler centrifuges
Finishing plant	3500 and 4000 liter Bycone dryers
	Hosakowa-micron 12S Finishing Mill
	Jet-Mill MS35, semi-automatic Operation
	800 Liter double cone blender

Helsinn Birex Pharmaceuticals Ltd

Producing mainly oral dosage forms (tablets and sachet) for the Helsinn Pharmaceutical Group partners has also capabilities for manufacturing topical forms. Available for contract manufacturing only in conjunction with Drug Substance manufacturing through one of the three Helsinn Chemical plants.

Oral dosage form formulation includes	Granulation, Blending, Tablets, Sachet Filling
Topical formulation	Mixer, Homogenizer, Gel Filling (tubes from 5 up to 100 grams)
Packaging & Cartoning	High-speed and low-speed cartining lines (blisters, small sachets, large sachets)
Gel Packaging & Cartoning	up to 160 cartons/ min
Vial Labeling & Cartoning	Labeler, automatic cartonner for 2&5 ml vials, up to 60 vials/min