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- POI: a transient paralysis of the gastrointestinal muscular system, possible cause of complications and prolongation of hospitalization following surgical operations -> remarkable impact on the healthcare costs.
- Ghrelin also has prokinetic effects on bowel motility.
- Ipamorelin has a positive pharmacokinetic profile (long half-life).
- Intravenous (infusion) formulation preliminarily available, optimization in progress to improve the stability at environment temperature.
- IND opened in 2006.
- 5 Phase I studies completed. 1 Phase IIa study currently on-going.
- Good safety profile, promising preliminary efficacy data (preclinical and Phase I) on bowel motility.
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